A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Synonyms: Benazepril [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
Term information
- CAS:86541-75-5
- KEGG:C06843
- DrugBank:DB00542
- MetaCyc:CPD-15329
- Reaxys:4302258
- LINCS:LSM-5609
- KEGG:D07499
- PMID:25912588
- PMID:25738503
- PMID:25224804
- HMDB:HMDB0014682
- Patent:US4410520
- PMID:25784709
- Drug_Central:299
- Wikipedia:Benazepril
- Patent:EP72352
3_STAR
Wikipedia:Benazepril
Reaxys:4302258
PMID:25738503
KEGG:D07499
Patent:US4410520
PMID:25224804
CAS:86541-75-5
HMDB:HMDB0014682
Patent:EP72352
PMID:25912588
KEGG:C06843
MetaCyc:CPD-15329
DrugBank:DB00542
PMID:25784709
Drug_Central:299
LINCS:LSM-5609
benazepril
benazeprilum
1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1