A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Synonyms: LOVASTATIN (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate Lovastatin lovastatin
Term information
- LINCS:LSM-2189
- PMID:18642339
- HMDB:HMDB0014372
- PDBeChem:803
- KEGG:D00359
- DrugBank:DB00227
- PMID:24093797
- PMID:11375168
- PMID:7720768
- KEGG:C07074
- PMID:11483865
- Patent:WO2013090461
- PMID:11389707
- KNApSAcK:C00000547
- Patent:CN103172602
- CAS:75330-75-5
- Beilstein:3631989
- Wikipedia:Lovastatin
- Reaxys:4720754
- Drug_Central:1612
3_STAR
PMID:7720768
KNApSAcK:C00000547
CAS:75330-75-5
PMID:11483865
PMID:18642339
PMID:11375168
HMDB:HMDB0014372
Patent:WO2013090461
Patent:CN103172602
PMID:11389707
Wikipedia:Lovastatin
PMID:24093797
Reaxys:4720754
Beilstein:3631989
KEGG:C07074
LINCS:LSM-2189
DrugBank:DB00227
PDBeChem:803
KEGG:D00359
Drug_Central:1612
6alpha-methylcompactin
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
Mevacor
2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
MK-803
ML-530B
Mevinolin
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1