A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.
Synonyms: (4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline Fosinopril
Term information
- LINCS:LSM-6485
- Patent:EP2264039
- KEGG:C07016
- PMID:18209565
- Patent:US2010297711
- Beilstein:8176492
- DrugBank:DB00492
- PMID:8285178
- PMID:22729889
- Patent:US4337201
- Patent:CN101367839
- CAS:98048-97-6
- KEGG:D07992
- PMID:9195116
- PMID:11937741
3_STAR
PMID:18209565
CAS:98048-97-6
PMID:11937741
LINCS:LSM-6485
KEGG:D07992
PMID:9195116
Patent:US4337201
PMID:8285178
Patent:EP2264039
Patent:US2010297711
DrugBank:DB00492
Beilstein:8176492
KEGG:C07016
PMID:22729889
Patent:CN101367839
(S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
(2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
fosinopril
InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30?,39?/m1/s1