A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Synonyms: Simvastatin (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Term information
- PMID:11336576
- Beilstein:4768037
- PMID:14561068
- PMID:18688862
- PMID:18936176
- PMID:18199328
- DrugBank:DB00641
- Patent:EP33538
- PMID:12827636
- LINCS:LSM-2492
- PMID:14973129
- KEGG:D00434
- CAS:79902-63-9
- Patent:US4444784
- Wikipedia:Simvastatin
- Drug_Central:2445
- HMDB:HMDB0005007
3_STAR
PMID:18936176
PMID:18688862
Beilstein:4768037
Patent:EP33538
PMID:12827636
LINCS:LSM-2492
Wikipedia:Simvastatin
Drug_Central:2445
Patent:US4444784
HMDB:HMDB0005007
CAS:79902-63-9
PMID:14973129
PMID:11336576
KEGG:D00434
DrugBank:DB00641
PMID:18199328
PMID:14561068
Simvastatina
MK-733
Simvastatinum
simvastatin
Zocor
Simvastatine
2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1