A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.
Synonyms: (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
Term information
- PMID:27215243
- Drug_Central:2712
- PMID:33660934
- PMID:25802524
- PMID:22247843
- Patent:KR20080046630
- PMID:23784370
- PMID:32964020
- PMID:8515499
- KEGG:D00383
- PMID:8515502
- PMID:25864194
- PMID:8515501
- PMID:8515504
- Reaxys:8655766
- PMID:34172790
- Chemspider:4588590
- PMID:9770740
- CAS:87679-37-6
- PMID:3383998
- DrugBank:DB00519
- Wikipedia:Trandolapril
- PMID:1648489
- PMID:26915813
- PMID:29319234
- Patent:WO2006014916
- HMDB:HMDB0014660
- PMID:19337528
- PMID:24835355
- PMID:8515500
3_STAR
KEGG:D00383
CAS:87679-37-6
PMID:24835355
Wikipedia:Trandolapril
PMID:9770740
PMID:22247843
PMID:1648489
PMID:8515501
PMID:25864194
PMID:8515500
PMID:32964020
PMID:8515502
Drug_Central:2712
PMID:8515504
Patent:WO2006014916
PMID:33660934
Patent:KR20080046630
PMID:23784370
Chemspider:4588590
PMID:27215243
PMID:19337528
PMID:25802524
HMDB:HMDB0014660
PMID:29319234
DrugBank:DB00519
PMID:34172790
PMID:26915813
PMID:8515499
PMID:3383998
Reaxys:8655766
trandolapril
trandolaprilum
RU 44570
RU-44570
Odrik
RU44570
(2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
Gopten
Mavik
InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1