Wnt signaling pathway
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PW_0000008 |
[The secreted glycoproteins of the Wnt family regulate a wide spectrum of developmental processes and they are also playing important roles in the adult organism. Deregulation of Wnt cascades has oncogenic effects and is responsible for tumorigenesis in adults.] |
NMDA receptor antagonist
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CHEBI_60643 |
[Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.] |
antagonist
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CHEBI_48706 |
[Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.] |
Pick's disease
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DOID_11870 |
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heart disease
|
DOID_114 |
[A cardiovascular system disease that involves the heart.] |
cardiovascular system disease
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DOID_1287 |
[A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.] |
sphingolipid
|
CHEBI_26739 |
[Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.] |
MAT1A
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OGG_3000004143 |
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loxapine
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CHEBI_50841 |
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CCAAT Enhancer Binding Protein
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NCIT_C17486 |
[A protein which binds to enhancers having a conserved CCAAT sequence. CCAAT enhancer binding proteins are a subclass of bZIP transcription factors that bind the CCAAT DNA sequence as homo- or heterodimers with other family members, C/EBP-alpha, beta, gamma, delta, epsilon. They include both transcriptional activators and repressors, and some are involved in myelopoiesis.] |
DNA Binding Protein
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NCIT_C16518 |
[Proteins that non-covalently interact with deoxyribonucleic acid as a result of intermolecular physical forces and spatial complementarity. Many genetic regulatory DNA binding proteins bind to double- or single-stranded DNA in a sequence-specific manner and share common structural motifs such as the zinc-finger, helix-turn-helix, and leucine zipper.] |
signal transduction
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GO_0007165 |
[The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.] |
age
|
PATO_0000011 |
[A time quality inhering in a bearer by virtue of how long the bearer has existed.] |
haloperidol
|
CHEBI_5613 |
[A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.] |
cell death
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GO_0008219 |
[Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).] |
amyloid-beta clearance
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GO_0097242 |
[The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.] |
cell culture
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BTO_0000214 |
[Cells taken from a living organism and grown under controlled conditions (in culture). Methods used to maintain cell lines or strains.] |
GAB2
|
OGG_3000009846 |
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Have Indigestion
|
NCIT_C125913 |
[A question about whether an individual has or had indigestion.] |
MBP
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OGG_3000004155 |
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