in vivo bioluminescence imaging system
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ERO_0000816 |
[An image acquisition instrument that is designed for non-invasive in vivo use, to detect bioluminescence, which is based on the expression of luciferase, the light-emitting enzyme of the firefly Photinus pyralis. After the administration of the substrate luciferin, an ATP- and O2-dependent photochemical reaction occurs, resulting in the release of photons by living cells containing luciferase. This photon emission can be detected by a cooled charge-coupled device (CCD) camera, minutes after the administration of the substrate.] |
GNB2L1
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OGG_3000010399 |
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Phosphatidylinositol 4,5-bisphosphate
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NCIT_C1192 |
[A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an intermediate that can be converted into either the second messenger signaling molecules, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), or phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3; PIP3). Both PIP2 and PIP3 can act as docking phospholipids, which recruit signaling proteins to the plasma membrane and promotes the activation of several signaling cascades.] |
MIR128-1
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OGG_3000406915 |
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iron(2+)
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CHEBI_29033 |
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Alzheimer disease 17
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MONDO_0014036 |
[An Alzheimer's disease that is characterized by an associated with mutations in the gene TREM2.] |
PVRL2
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OGG_3000005819 |
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pioglitazone
|
CHEBI_8228 |
[A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.] |
locus ceruleus
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UBERON_0002148 |
[The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].] |
brainstem nucleus
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UBERON_0006331 |
[A nucleus of brain that is part of a brainstem.] |
biopterins
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CHEBI_22881 |
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pterins
|
CHEBI_26375 |
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FOXO1
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OGG_3000002308 |
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INPP5D
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OGG_3000003635 |
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biphenyls
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CHEBI_22888 |
[Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.] |
biaryl
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CHEBI_64459 |
[An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond.] |
ring assembly
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CHEBI_36820 |
[Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.] |
benzenoid aromatic compound
|
CHEBI_33836 |
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INSR
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OGG_3000003643 |
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malfunctioning process
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TXPO_0000434 |
[Malfunctioning process is a subtype of function-related process: A process that cannot perform a function appropriately or cannot realize it at all.] |