A mitochondrial metabolism disease characterized by a wide range of manifestations including marked and often fatal lactic acidosis, cardiomyopathy, leukoencephalopathy, pure myopathy and hepatopathy with tubulopathy. Among the numerous clinical phenotypes observed are Leigh syndrome, Leber hereditary optic neuropathy and MELAS syndrome. It can have material basis in mutations in multiple different genes, both nuclear-encoded and mitochondrial-encoded. [ http://purl.obolibrary.org/obo/ECO_0007636 url:http://www.omim.org/entry/252010 ]
Synonyms: isolated NADH-coenzyme Q reductase deficiency isolated NADH-ubiquinone reductase deficiency isolated NADH-CoQ reductase deficiency isolated mitochondrial respiratory chain complex I deficiency
Term information
- MESH:C537475
- UMLS_CUI:C1838979
- SNOMEDCT_US_2023_03_01:237988006
- ORDO:2609
- GARD:3908
DO_rare_slim