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Neu-Laxova syndrome 1
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DOID_0080076 |
[A serine deficiency that is characterized by multiple fatal malformations including ichthyosis, microcephaly, central nervous system abnormalities, limb deformities, intrauterine growth restriction, proptosis, anasarca, and micrognathia, and has_material_basis_in autosomal recessive inheritance of mutation in the PHGDH gene on chromosome 1p12, causing issues producing the amino acid serine.] |
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hypophosphatemic nephrolithiasis/osteoporosis 1
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DOID_0080077 |
[A hypophosphatemic nephrolithiasis/osteoporosis that has_material_basis_in heterozygous mutation in the SLC34A1 gene on chromosome 5q35.] |
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mucolipidosis II alpha/beta
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DOID_0080070 |
[A mucolipidosis that is characterized by short stature, skeletal abnormalities, cardiomegaly, and developmental delay, caused by a defect in proper lysosomal enzyme phosphorylation and localization, which results in accumulation of lysosomal substrates, and that has_material_basis_in homozygous or compound heterozygous mutation in the GNPTAB gene.] |
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mucolipidosis III alpha/beta
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DOID_0080071 |
[A mucolipidosis that has_material_basis_in mutation in the gene encoding the alpha/beta-subunits precursor gene of GLcNAc-phosphotransferase.] |
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intestinal pseudo-obstruction
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DOID_0080072 |
[A colonic disease that is characterized by bowel obstruction resulting from impairment of the muscle contractions that move food through the digestive tract.] |
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spina bifida occulta
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DOID_0080073 |
[A spina bifida that is characterized by minor splits in the vertebrae where the outer part of some of the vertebrae is not completely closed.] |
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Abnormal chorioretinal morphology
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HP_0000532 |
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obsolete sorbitol dehydrogenase deficiency with peripheral neuropathy
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DOID_0081376 |
[A neuromuscular disease that is characterized by onset of distal muscle weakness mainly affecting the lower limbs and resulting in difficulty walking and that has_material_basis_in homozygous or compound heterozygous mutation in the SORD gene on chromosome 15q21.] |
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Kniest dysplasia
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DOID_0080045 |
[An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.] |
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Stickler syndrome
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DOID_0080046 |
[A syndrome that is characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems.] |
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pseudoachondroplasia
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DOID_0080047 |
[An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism.] |
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amyotrophic lateral sclerosis type 24
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DOID_0081378 |
[An amyotrophic lateral sclerosis that is characterized by adult-onset loss of motor neurons and that has_material_basis_in heterozygous mutation in the NEK1 gene on chromosome 4q33.] |
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amyotrophic lateral sclerosis
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DOID_332 |
[A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.] |
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obsolete trichorhinophalangeal syndrome I
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DOID_0080048 |
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amyotrophic lateral sclerosis type 25
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DOID_0081379 |
[An amyotrophic lateral sclerosis that is characterized by rapidly progressive muscle weakness and death due to respiratory failure and that has_material_basis_in heterozygous mutation in the KIF5A gene on chromosome 12q13. ALS25 may have a lower median age at onset (46.5 years) and longer median survival (10 years) than that found in epidemiologic studies (62.5 years and 20 to 30 months, respectively).] |
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obsolete neoplasm of body of uterus
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DOID_5070 |
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obsolete meninges gliomatosis
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DOID_5072 |
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obsolete central nervous system soft tissue neoplasm
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DOID_5071 |
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basosquamous carcinoma
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DOID_5063 |
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phencyclidine abuse
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DOID_5062 |
[A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.] |