brain-derived neurotrophic factor signaling pathway
Go to external page http://purl.obolibrary.org/obo/PW_0000572
This is just here as a test because I lose it
Term information
definition
Brain-derived neurotrophic factor (BDNF) signaling pathway plays important roles in the growth, differentiation and survival of neurons, particularly the striatal neurons. BDNF signals via the tropomyosin-related kinase receptor type B (TrkB) to activate PKC, PI3K-AKT and MAPK/ERK intracellular pathways. Impaired BDNF signaling contributes to the pathogenesis of conditions such as Huntington Disease (HD) and psychiatric disorders. Upregulation on the other hand, is associated with several malignancies.