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The release of a drug from a drug delivery system (DDS) involves both dissolution and diffusion. Several mathematical equations models describe drug dissolution and/or release from DDS. In the modern era of controlled-release oral formulations, 'Higuchi equation' has become influential kinetic equation in its own right, as evidenced by employing drug dissolution studies that are recognized as an important element in drug delivery development. Today the Higuchi equation is considered one of the widely used and the most well-known controlled-release equation. T. Higuchi developed an equation for the release of a drug molecule from creams and ointments in 1960 (Higuchi, T., J. Soc. Cosmetic Chem., 1960, 11:85-97). source: http://www.pharmabiz.com/article/detnews.asp?articleid=36525&sectionid=46