Carbon disulphide
Go to external page http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#Carbon_disulphide
Term information
Jankovic, J. J. T. E., & Tolosa. (2007). Parkinson's disease and movement disorders. E. Tolosa (Ed.). Lippincott Williams & Wilkins.
Carbon disulfide, usually in solvents or pesticides, can cause Parkinson's disease that is associated with other neurological symptoms. The toxic effects can persist for years after exposure to the carbon disulfide has ceased. Potential sources include pesticides used as fumigants, disulfiram (a drug used in the treatment of chronic alcoholism), industrial solvents, solvents used in the production of viscose rayon and cellophane film. Means of toxicity is not established. However, carbon disulphide interferes with pyridoxal 5-phosphate. Pyridoxal 5-phosphate is essential for the formation of dopamine from L-dopa. So carbon disulphide may cause Parkinson's disease symptoms by reducing the formation of L-dopa.