Logroscino, G. (2005). The role of early life environmental risk factors in Parkinson disease: what is the evidence?. Environmental health perspectives, 113(9), 1234.

Exposure to environmental neurotoxicants can determine progressive damage in the substantia nigra many years before the onset of clinical parkinsonism. Therefore, PD, like other neurologic diseases related to aging, may be determined by exposures present in the environment early during the life span or even during pregnancy.