Reeve, A. K., Krishnan, K. J. and Turnbull, D. (2008), Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration. Annals of the New York Academy of Sciences, 1147: 21–29. doi: 10.1196/annals.1427.016

The mitochondrial dysfunction caused by mutations has been shown to be associated with signs of apoptosis and to cause cell loss. Mutations of the mitochondrial genome have also been shown to accumulate with age and in common neurodegenerative diseases, such as Parkinson's disease.

mitochondrial DNA mutations in early parkinson

Mitochondrial Dysfunction in Idiopathic Parkinson Disease

Mutations in mitochondrial DNA