This is just here as a test because I lose it

Term information

Author

Thrishna

CommentOnDefinition

Definition modified

CommentOnHierarchy

No reference ontology to BFO classification available. 'NR4A2 knockout model' is a 'transgenic model'. 'transgenic model' is classified under BFO class 'information content entity' and so is 'NR4A2 knockout model'.

oboInOwl:hasDbXRef

https://www.ncbi.nlm.nih.gov/pubmed/16631355

oboInOwl:hasDefinition

Mice models lacking Nurr1, disrupting midbrain dopaminergic neuron development. Heterozygous Nurr1 knockout (+/-) mice show deficient mesolimbic/mesocortical dopamine levels, including reduced dopamine levels in the prefrontal cortex and nucleus accumbens, along with a hyperlocomotor response to stress, suggesting a possible gene–dose effect on dopamine production in these regions.

oboInOwl:hasExactSynonym

Nurr1 knockout mice

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