NR4A2 knockout mouse model
Go to external page https://bio.scai.fraunhofer.de/ontology/schizophrenia#NR4A2_knockout_mouse_model
This is just here as a test because I lose it
Term information
CommentOnHierarchy
No reference ontology to BFO classification available. 'NR4A2 knockout model' is a 'transgenic model'. 'transgenic model' is classified under BFO class 'information content entity' and so is 'NR4A2 knockout model'.
oboInOwl:hasDefinition
Mice models lacking Nurr1, disrupting midbrain dopaminergic neuron development. Heterozygous Nurr1 knockout (+/-) mice show deficient mesolimbic/mesocortical dopamine levels, including reduced dopamine levels in the prefrontal cortex and nucleus accumbens, along with a hyperlocomotor response to stress, suggesting a possible gene–dose effect on dopamine production in these regions.