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dizocilpine model

Go to external page https://bio.scai.fraunhofer.de/ontology/schizophrenia#dizocilpine_model

This is just here as a test because I lose it

Term information

Author

Thrishna

CommentOnDefinition

Definition modified

CommentOnHierarchy

No reference ontology to BFO classification available. 'dizocilpine model' comes under 'uncompetitive N-methyl-D-aspartate receptor antagonist model'. 'uncompetitive N-methyl-D-aspartate receptor antagonist model' comes under 'glutamatergic model'. 'glutamatergic model' is classified under BFO class 'information content entity' and so is 'dizocilpine model'.

oboInOwl:hasDbXRef

https://www.ncbi.nlm.nih.gov/pubmed/29188780

https://www.ncbi.nlm.nih.gov/pubmed/25653831

https://www.ncbi.nlm.nih.gov/pubmed/29742910

oboInOwl:hasDefinition

Animal model mimic the full spectrum of schizophrenic disorder including positive and negative symptoms along with cognitive deficits with the administration of dizocilpine. Dizocilpine (MK-801) is N-methyl-D-aspartate (NMDA) receptor antagonist known to induce hyper-locomotion and stereotyped behavior in rodents. Dizocilpine injected rats exhibited significant hyperlocomotor behavior, depressive symptoms and cognitive deficits.