post-weaning social isolation model
Go to external page https://bio.scai.fraunhofer.de/ontology/schizophrenia#post-weaning_social_isolation_model
Term information
No reference ontology to BFO classification available. 'post-weaning social isolation model'comes under 'neurodevelopmental model'. 'neurodevelopmental model' is an animal model. 'animal model' is classified under BFO class 'information content entity' and so is 'post-weaning social isolation model'.
https://www.ncbi.nlm.nih.gov/pubmed/21449915
https://www.ncbi.nlm.nih.gov/pubmed/29742910
Animals models in which social structure of rat pups is disturbed from the age of weaning. Post-weaning social isolation of rodents induces spontaneous locomotor hyperactivity, enhanced responses to novelty (neophobia), sensorimotor gating deficits, cognitive impairments, and heightened anxiety states and aggression. Collectively, these behavioural changes have been termed the ‘isolation syndrome’, and several of these features resemble some of the core symptoms of schizophrenia.